Specific growth rate estimation in (fed-)batch bioreactors using second-order sliding observers

Specific Growth Rate and Sliding Mode Stabilization of Fed-Batch Processes

Noncommercial 3.0 Unported License http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction inany medium, provided the original work is properly cited. Global Journal of Computer Science and Technology Volume 11 Issue 20 Version 1.0 December 2011 Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals I...

Fed-batch Cultivation of Recombinant Escherichia coli Producing Human Interferon-γ Under Controlled Specific Growth Rate

Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes

The real-time measurement of biomass has been addressed since many years. The quantification of biomass in the induction phase of a recombinant bioprocess is not straight forward, since biological burden, caused by protein expression, can have a significant impact on the cell morphology and physiology. This variability potentially leads to poor generalization of the biomass estimation, hence is...

Feedback stabilization of fed-batch bioreactors: non-monotonic growth kinetics.

This paper deals with the design of a feedback controller for fed-batch microbial conversion processes that forces the substrate concentration C(S) to a desired setpoint, starting from an arbitrary (initial) substrate concentration when non-monotonic growth kinetics apply. This problem is representative for a lot of industrial fermentation processes, with the baker's yeast fermentation as a wel...

On the State Estimation of Structures with Second Order Observers